Cathinone is a naturally occurring amphetamine found in khat

Cathinone /ˈkæθɪnoʊn/ (also known as benzoylethanamine, or β-keto-amphetamine) is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine, methcathinone and other amphetamines. It is probably the main contributor to the stimulant effect of Catha edulis.

Cathinone is a naturally occurring amphetamine found in khat (Catha edulis). It’s rarely used outside of khat, where it works in combination with other drugs to provide fairly typical stimulant effects. 

Occasionally it’s been sold on its own, but cathinone itself is a rare product. Khat, however, is used by millions of people every day. Cathinone is a naturally occurring amphetamine found in khat

The drug offers amphetamine-like effects, including stimulation, mood lift, and increased cardiovascular activity. Khat has long been used to facilitate social interaction, to provide stimulation, and to decrease hunger.

Cathinone serves as the base structure for a large class of drugs, the substituted cathinones.


Cathinone = benzoylethanamine; β-keto-amphetamine; beta-keto-amphetamine; (S)-(-)-Cathinone

PubChem: 62258

Molecular formula: C9H11NO

Molecular weight: 149.193 g/mol

IUPAC: (2S)-2-amino-1-phenylpropan-1-one

Dose

Oral (tentative)

Common: 30 – 60 mg

We don’t have good dosing information for cathinone itself.

Khat is typically chewed during 3 to 5-hour sessions and an estimated 100 – 300 grams is used per session. That’d come out to 30 to 100 mg of cathinone per use, but the amount of cathinone exposure could vary significantly.

The plant is most often chewed or made into a tea. Occasionally it’s been smoked.

Khat users tend to prefer fresh leaves and they chew intermittently to enhance the absorption.

Timeline

Oral

Total: 2 – 4 hours

Onset: 00:15 – 01:00

Typically people use khat over a period of hours, with the effects peaking around 90 to 210 minutes after the session begins.

In pharmacokinetic studies, cathinone is almost undetectable at both T+00:30 and T+07:30.

Cathinone is a naturally occurring amphetamine found in khatCathinone is a naturally occurring amphetamine found in khat

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