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Introduction – Buy Phenethylamine drugs online
General public has long been aware of traditional illicit drugs such as cocaine, marijuana, and methamphetamine. Designer drugs were created in the 1960s to avoid the provisions of existing drug laws by preparing analogs or derivatives of currently available drugs. Designer drugs including the 2C class discussed in this article are not new but have been increasing in popularity. Manufacturers of designer drugs purposely change the structure of these drugs to stay ahead of drug laws, making it difficult for clinicians to stay informed. Structure manipulation to produce new compounds, advertisement of these compounds as “legal” highs, and ease of access of designer drugs from the internet, raves, night clubs, and sale in head shops have rejuvenated and promoted the current designer drug resurgence [1, 2].
The 2Cs are just one of the designer drug classes currently being promoted and disseminated on the internet and at raves. The phenethylamine-based structure is actually shared among amphetamines, catecholamines, cathinones, and many other drugs. The terminology “2Cs” is in reference to an acronym invented by Alexander Shulgin to describe the two carbons between the amino group and the benzene ring in the chemical structure (Fig. 1) [3, 4]. In this article, we will continue to use “2C” to refer to the group of newly substituted designer hallucinogens with methoxy groups at the 2 and 5 positions on the ring, rather than the larger group of phenethylamine-based compounds that would include epinephrine, dopamine, bupropion, MDMA, methamphetamine, cathinones, and a multitude of other commonly known similarly structured agents.
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Phenethylamines refer to a class of substances with documented psychoactive and stimulant effects and include amphetamine, methamphetamine and MDMA, all of which are controlled under the 1971 Convention.The phenethylamines also include ring substituted substances such as the ‘2C series’, ring substituted amphetamines such as the ‘D series’ (e.g DOI, DOC), benzodifurans (e.g. Bromo-Dragonfly, 2C-B-Fly) and others (e.g. p-methoxymethamphetamine (PMMA)).
Phenethylamines Seizures were first reported from the United States and European countries . Substances such as 2C-E, 2C-I, 4-FA and PMMA have been commonly reported by several countries in different regions. Other phenethylamines increasingly reported to UNODC since 2011 include 4-FMA, 5-APB, 6-APB and 2C-C-NBOMe.
A number of studies have reported the synthesis of some phenethylamines and amphetamine substitutes. In the 1980s and 1990s, Alexander Shulgin, a biochemist and pharmacologist, reported the synthesis of numerous new psychoactive compounds.This included the ‘D series’ (e.g. DOC, DOI) and the ‘2C series’ (e.g. 2C-T-7, 2C-T-2) of phenethylamines.
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New groups of synthetic “designer drugs” have increased in popularity over the past several years. These products mimic the euphoric effects of other well-known illicit drugs but are advertised as “legal” highs and are sold over the internet, at raves and night clubs, and in head shops. The 2C series drugs are ring-substituted phenethylamines that belong to a group of designer agents similar in structure to 3,4-methylenedioxy-N-methylamphetamine (MDMA, Ecstasy). Understanding the pharmacology and toxicology of these agents is essential in order to provide the best medical care for these patients. This review focuses on the pharmacology, pharmacokinetics, clinical effects, and treatment of 2C drug intoxication based on available published literature. Under which 2C drugs are sold , multiple names were identified and tabulated. Common features identified in patients intoxicated with 2Cs included hallucinations, agitation, aggression, violence, dysphoria, hypertension, tachycardia, seizures, and hyperthermia. Patients may exhibit sympathomimetic symptoms or symptoms consistent with serotonin toxicity. An excited delirium presentation seems to be consistent amongst deaths attributed to 2C drugs; Five deaths have been reported in the literature in patients intoxicated with 2C drugs. 2C drugs are a group of designer intoxicants, many of which are marketed as legal, but may carry risks that consumers are unaware of. These drugs may be characterized by either serotonergic toxicity or a sympathomimetic toxidrome, but a presentation consistent with excited delirium is consistent amongst the reported 2C-related deaths. Treatment of 2C intoxication is primarily supportive, but immediate action is required in the context of excited delirium, hyperthermia, and seizure activity.
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